Post Breeze/Race Remodeling II

On with the metaphysics of equine bone remodeling. Speculation as a manner of inquiry began, after all, with Socrates. We presume the stars are all aligned, and the biologic materials will react in an ordered universe just as God intended.

So, if as Remodeling I hypothesized, there is more to equine bone remodeling than human, and that one of the results from the speed event is a compaction of bone glue material leaving behind nano spacing, how long before those atomic size vacuums are filled with new bone glue, and, just as interestingly for the subject, after they have filled in, under what circumstances will they stay that way?

Anyone that's filled a grease gun or dealt with one of those machine grease canisters understands the powerful resistance when such material has sufficiently compacted. You can only squeeze the canister closed so far before the grease starts pushing back. And so, we may imagine, do bone glue proteins buttress up our mineralized, non-mineralized or partially mineralized collagen cells in that the greater the density the stronger the FR.

Hansma (to review--see images at bottom of post) puts this in perspective:

"Our findings so far on fracture resisting properties of adhesive noncollagenous bone proteins are, in summary, that they exist as substantial contributors to the overall fracture toughness in bone"

Let's us note that I've read nothing in Hansma about a "buttressing effect". Hansma deals more with the bonding of the bone glue, but he's looking at humans instead of horses.

But, we do know from Hansma and other research how bone glue proteins are layed down. Essentially this organic material bleeds out from the capillaries and then reacts enzymatically with other substances at the molecular and atomic level which creates its character. I'm sort of considering that bone glue might be the muck left over when the other chemical-atomic processes of collagen formation and mineralization have taken place, which would be a reason that bone glue is omnipresent throughout the molecules.

If you think about how the material gets to its location in the first place, and what process probably stops additional material from arriving, some probably sound conclusions are possible.

We may imagine that all this material arrives within the bone by leaking out from capillaries. But, as spacing fills, the leakage decreases as pressure from without starts to equal pressure from within. At some point the process of (physical) equilibrium is reached and further material can leak out only where additional space is created.

And, when you consider, the action of the forces of the breeze upon the bone materials at the microscopic level will create spacing in two ways: 1. by compaction, and 2. by heat expansion.

The compaction effect has been discussed. What about the heat effect which presumably might thin the bone glue aiding in its contraction? But, we'd expect the opposite effect of heat on the harder/hardened mineralized and non-mineralized collagen in that heat would cause these materials to expand.

AND, since this heat effect of expansion will last 12 to 24 hours and sometimes longer post race (feel your horse's cannon after race), which might also have the effect of expanding capillaries and speeding up the flow of material, can we think that much more material is going to be deposited from the capillaries into the nano spacing immediately post breeze than when the whole thing cools down.

AND, after the cool down there will still be an accelerated deposition of materials out of the capillaries because the spacing previously created will lower the pressure surrounding these blood vessels which will have thus accelerate depositing until an equilibrium again is created.

Thus, I'm thinking that fairly quickly post breeze/race there will be additional materials present in newly created spacing which will combine with the bone glue muck already there. And, let's put this in %. Let's say the existing bone glue post breeze will contract and everything else expand due to heat leaving 5% spacing that will quickly be filled up (within 48 hours). The 5% of new material then would combine with the old by OSMOSIS to create another equilibrium (materials spread throughout the medium in equal amounts), SO THAT THE BONE GLUE POST RACE WILL BE VIRTUALLY IDENTICAL TO ITS CONSISTENCY PRE-RACE EXCEPT THERE WILL BE MORE OF IT!!!!!!!!!!!!!!!!!!!!!!!!!!!!!

There. Asked and answered. Next (after the Florida Derby, of course): How long and under what circumstances might increase in bone glue volume last is next.

Training:
Thurs. 3/26. After 2 days off we'll be back at it. Trailer in the shop for major surgery. An adjustable coupler on the tongue will be installed to cause the trailer floor to parallel the ground. The 18 inch wheels (as opposed to 17) on the new truck combined with an extra inch on the heavy duty gooseneck caused the trailer to sit at a 20 degree angle from the ground.

Below some Hansma images of bone glue revisted. Notice the 500nn size. This is large. Hansma's website has images all the way down to 50nn.
"A" shows collagen fibrils filled with bone glue.
"B" shows unmineralized colagen fibrils.
"C" shows mineralized collagen fibrils.
"D" shows crack formation in the "non-fibullar organic matrix.