More Bone Mechanics
All human research I've seen deals with fracture resistance (FR) relating to osteoporosis, but how interesting that momentary to my latest article off the net, KH comments (last post) from Testosterone Nation
http://www.tmuscle.com/index.jsp
one of the better exercise physiology sites, and another example why I spend too much time on the computer.
My new discovery comes from the Southwest Research Institute, San Antonio, TX., without a date, but surely it's recent. Interesting that others deal with the same questions posed on this blog as the mere posing of the question on the research pages seems to validate that respecting horse cannons possibly the blog here is at least on the right track. Main points of the article:
1. General quest of the research: "The bone mechanics research program is focused on understanding the relationship between bone mechanical and biological functions, advanced characterization of bone tissue material and mechanical properties, and developing and applying advanced engineering methods to predict an individuals' risk of bone fracture."
hmmmm.
2. "A major goal of this program is to determine osteocyte function in response to mechanical loading."
Seems to be on subject.
3. "To accomplish this goal (they are gong to give us a method!!!) it will be necessary to relate osteocyte deformation and/or strain in bone tissue to the expression and function of different molecules expressed by osteocytes in response to mechanical loading.
i.e. our precise question, but for equines!
4. they pose the question "what role that mechanical strain (both internal and external!) plays in osteocyte biology."
5. They are going to "load" cells and then "image" the loaded cells which "enables the quantification of individual cell deformations."
cell deformation--that's the term! Previously the blog had referred to "contraction" and "rebounding" as key remodeling concepts.
they are referring to "physical deformation of osteocytes due to different mechanical stimulation.
6. "Data from our lab suggest that the hypothesis that bone cells do not respond to bone matrix strain may be incorrect."
taking us back to the KH comment, last post!
7. This seems really really important: They apply a certain level of mechanical stress. Unclear whether they're using live or dead bone. "We have shown that in vitro osteocyte cell deformation due to this level of shear stress can be between approximately 5,000 and 50,000 microstrain with a concomitant biological response measured as an increase in PGE2 production.
what is PGE2, next post.
the entire page appears here:
http://www.swri.org/cms/Index.asp?ID=38
Training:
Wed and Thurs. 11/25/26: two pasture romps with some fast licks.
Fri. 11/27: Each horse was tacked at walk trot 1.6 miles.
http://www.tmuscle.com/index.jsp
one of the better exercise physiology sites, and another example why I spend too much time on the computer.
My new discovery comes from the Southwest Research Institute, San Antonio, TX., without a date, but surely it's recent. Interesting that others deal with the same questions posed on this blog as the mere posing of the question on the research pages seems to validate that respecting horse cannons possibly the blog here is at least on the right track. Main points of the article:
1. General quest of the research: "The bone mechanics research program is focused on understanding the relationship between bone mechanical and biological functions, advanced characterization of bone tissue material and mechanical properties, and developing and applying advanced engineering methods to predict an individuals' risk of bone fracture."
hmmmm.
2. "A major goal of this program is to determine osteocyte function in response to mechanical loading."
Seems to be on subject.
3. "To accomplish this goal (they are gong to give us a method!!!) it will be necessary to relate osteocyte deformation and/or strain in bone tissue to the expression and function of different molecules expressed by osteocytes in response to mechanical loading.
i.e. our precise question, but for equines!
4. they pose the question "what role that mechanical strain (both internal and external!) plays in osteocyte biology."
5. They are going to "load" cells and then "image" the loaded cells which "enables the quantification of individual cell deformations."
cell deformation--that's the term! Previously the blog had referred to "contraction" and "rebounding" as key remodeling concepts.
they are referring to "physical deformation of osteocytes due to different mechanical stimulation.
6. "Data from our lab suggest that the hypothesis that bone cells do not respond to bone matrix strain may be incorrect."
taking us back to the KH comment, last post!
7. This seems really really important: They apply a certain level of mechanical stress. Unclear whether they're using live or dead bone. "We have shown that in vitro osteocyte cell deformation due to this level of shear stress can be between approximately 5,000 and 50,000 microstrain with a concomitant biological response measured as an increase in PGE2 production.
what is PGE2, next post.
the entire page appears here:
http://www.swri.org/cms/Index.asp?ID=38
Training:
Wed and Thurs. 11/25/26: two pasture romps with some fast licks.
Fri. 11/27: Each horse was tacked at walk trot 1.6 miles.
posted by rather rapid at
12:47 PM
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