Wednesday, June 17, 2009

Osteoblast/Clast Remodeling


"Now consider conjecture of a time...". A group of Osteoblasts sits in deep discussion:

Seargent: Full report.

Osteoclast #1: Sgt., space to lay down 10 non-mineralized collagen fibrils has been cleared.

Sgt. Excellent #1. Let's get to work my friends.

Three weeks later:

Sgt. Report.

Osteoblast #1: Sgt., new baby fibrils have been laid.

Sgt.: How many?

Osteoblast #1: ten new babies.

Sgt. Ten it is. Let's mineralize 'em.

Suddenly the proceedings are interrupted. The owner of this group of cells has jumped out of the starting gate.

Osteo #2. Whoa.

Osteo #3: Whoa, we're rocking.

Osteo #4: Whoa big fellow.

200 thuds later:

Sgt. Dammmm...whatever, look at our babies.

Osteo #1: They're squeezed.

Osteo #2: They're compressed.

Osteo#3: They're crushed.

Sgt. Never mind, men. It looks like we have room for one more.

Osteo #1: We have room for 11 now instead of 10.

Sgt. That appears to be the case.

8 days later.

Sgt. Report:

Osteo #1: Unknown what happened. That space for the 11th baby disappeared.

Sgt. Any explanation?

Osteo #2: Plecher.

Sgt.: Ahh, Plecher.


Plecher of course has kept the horse out of speed work for 3 weeks post race giving the newly laid non-mineralized collagen fibrils time to rebound back to their original shape, thus filling in any microspacing created around them by the event, and therefore eliminating the ability to increase the density of the new fibrils by adding to their original number. Our Plecher horse, theoretically will have less dense new bone due to the manner of his training!!!

How soon Plecher needed to do additional speed work that would have reinforced the spacing created is the question, of course. Look at this with respect to new fibrils, next post.

Training:
Tues. 6/16: Off. Another 1.24 inches of rain.

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